Grant Success! Bladder Cancer

Picture caption: The team: Back row left to right: Mr Matthew Perry – Consultant Urological Surgeon,Gregory Nason – Senior Clinical Fellow, and Mr Hugh Mostafid – Consultant Urological Surgeon. Front row left to right: Tyler Wooldridge – PhD student, and Dr Nicola Annels – Senior Research Fellow.

The Urological Oncology group have recently been awarded a small grant from Action Bladder Cancer UK

for £9,311.00 to help fund our project: Urinary microbiome as a predictor of response to Bacillus Calmette-Guerin (BCG) immunotherapy in non-muscle invasive bladder cancer. This project will be carried out by Dr Nicola Annel’s PhD student, Tyler Wooldridge, in collaboration with Matt Perry and Hugh Mostafid, Urology Consultants at the Royal Surrey County Hospital .

– PROJECT SUMMARY –
The patient’s bladder microbiome (bacteria in bladder lining) may have a role in development of bladder cancer and its response to immunotherapies.
The project team will investigate differences in microbial composition of bladder tumour tissue and urine between patients with recurrence (BCG-failure), and without recurrence potentially providing a predictive marker for response to BCG therapy. Analysis of the patient’s tumour immune-microenvironment will reveal the role the microbiome plays in shaping the bladder immune response. Understanding the alteration of bacterial composition in bladder cancer could lead to the bladder microbiome of patients being used as a modifiable way to optimise response to immunotherapy.

Share This Post

Share on facebook
Share on linkedin
Share on twitter
Share on email

More To Explore

Michael Buerk
Events

An evening with Michael Buerk.

Please join us on Zoom with our very special guest Michael Buerk on the 18th March at 7.00pm. Michael is one of Topic of Cancers

Community Foundation for Surrey.
Fundraising

Community Foundation for Surrey

The Community Foundation for Surrey supports fundraising for many different projects – Topic of Cancer has benifited from their Support. Here’s some more information from